1(2H)-Pyrimidinecarboxamide, 5-fluoro-3,4-dihydro-2,4-dioxo-N-phenyl-
PluriSIn #2
CAS: 56563-17-8
Molecular Formula: C11H8FN3O3
1(2H)-Pyrimidinecarboxamide, 5-fluoro-3,4-dihydro-2,4-dioxo-N-phenyl- - Names and Identifiers
| Name | PluriSIn #2 |
| Synonyms | 1-Phenylcarbamoyl-5-fluoroureacil 1(2H)-Pyrimidinecarboxamide, 5-fluoro-3,4-dihydro-2,4-dioxo-N-phenyl- |
| CAS | 56563-17-8 |
1(2H)-Pyrimidinecarboxamide, 5-fluoro-3,4-dihydro-2,4-dioxo-N-phenyl- - Physico-chemical Properties
| Molecular Formula | C11H8FN3O3 |
| Molar Mass | 249.2 |
| Appearance | Solid |
| Storage Condition | 2-8°C，密封，干燥 |
| In vitro study | PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level. A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them. Western Blot Analysis Cell Line: B153 and HUES9 human pluripotent stem cells (hPSCs) Concentration: 20 µM Incubation Time: 12 hours Result: Reduced TOP2A expression at the protein level. |
1(2H)-Pyrimidinecarboxamide, 5-fluoro-3,4-dihydro-2,4-dioxo-N-phenyl- - Reference Information
| Biological activity | PluriSIn #2 is a selective transcription inhibitor of topoisomerase IIα (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSC). |
| target | topoisomerase II alpha |
| in vitro study | PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level. A 24h exposure of PluriSIn #2 (20 µm) is sufficient to induce massive cell death in hPSCs, but doesn't affect the viability of various other cell types derived from them. Western Blot Analysis Cell Line: b153 and HUES9 human pluripotent stem cells (hPSCs) Concentration: 20 µM Incubation Time: 12 hours Result: Reduced TOP2A expression at the protein level. |
| Cell Line: | B153 and HUES9 human pluripotent stem cells (hPSCs) |
| Concentration: | 20 µM |
| Incubation Time: | 12 hours |
| Result: | Reduced TOP2A expression at the protein level. |
Last Update：2024-04-09 21:50:46
